The Shackle of Despair is one of the enemies in the Brain of Denial boss fight. Moves: -Denial of Reason, cannot use stress healing skills -Overwhelming Anguish (From rank 4, targets rank 1) 8=14 dmg, 3-4 stress -Crippling Doubt (From Rank 4, targets ranks 1 and 2) 6 damage to each, 1 -2 stress to each -Paralyzing Fear (From Rank 3-4, targets Rank 1,3) 4-6 damage, Stuns, adds Vulnerability.